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Ligandrol Silver Pharm

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Ligandrol Silver Pharm

Conclusion from the results of the study sample of the drug Ligandrol.

Head of Chemical Analytical Laboratory, LLC IFC Silver Farm

D.S. Gaybo

2014

Name of the analyte: Sample of unknown composition, presumably LGD
 (LGD-4033, Ligandrol is a synthetic peptide drug.)
  Appearance of the preparation: colorless powder in a capsule of white-green color.
  Dissolution: The sample was dissolved in methanol. Appearance after dissolution - transparent
 colorless liquid.
  Analysis Method: Purity Definition: HPLC with Diode Array Detector (Agilent 1100
 series, HPLC-DAD). Detection λ = 210 nm. Qualitative analysis: HPLC with tandem
 quadrupole time-of-flight mass detector (Agilent 6530 Accurate-Mass Q-TOF, HPLC-MS).
  Chromatographic analysis conditions: column: Thermo Gold aQ 150 × 2.1 mm 3 μm; mobile
 phase: A: 100% H O/0.01% TFA (v/v), B: 10% H O/90% ACN/0.01% TFA (v/v/v); flow rate: 0.5 2 2
 ml/min; thermostat temperature: 30 ° C; detection: UV 210 nm, input volume - 20μl.
 
 HPLC-DAD analysis results:
 
 
 
 
  Figure 1 is a chromatogram of an LGD sample being analyzed.
 
 The chromatogram (Fig. 1) has a peak with a retention time of 15.7 min and an absorption spectrum in the UV
 the area (Fig. 2) corresponds to the LGD.
 
 
 
  Figure 2 - UV spectrum of the analyzed LGD sample
  (wavelength range 190 - 400 nm).
 
 
 
  Figure 3 is the mass spectrum of the analyzed LGD sample, RT = 15.71.
 
 
 
 
 
  Figure 4 - Tandem mass spectrum (699.16- & gt; *) of the analyzed LGD sample, RT = 15.71.
 On the mass spectrum (Fig. 3), a peak of 699, 1612 ± 0.0008 m/z and the isotopic distribution correspond to
 single charged ion [LGD + H]. On the tandem mass spectrum (Fig. 4) fragmentation ions,
 formed during the splitting of the parent ion with m/z = 454.08, confirm the structural
 similarity of the analyzed sample with the compound LGD.
 
  Conclusion.
 
 In a sample of unknown composition, the substance LGD is identified. Total impurities not more than 0.1
 % Sample purity not less than 99.9%.